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(The University of Connecticut)

The University of Connecticut (UConn) is a public research university in the U.S. state of Connecticut. Founded in 1881 as a land-grant university, UConn serves more than 28,000 students on its six campuses, including nearly 8,000 graduate students in multiple programs. UConn's main campus is in Storrs, Town of Mansfield. The university's president is Dr. Michael J. Hogan, noted historian and former provost of the University of Iowa.

More information: http://en.wikipedia.org/wiki/University_of_Connecticut

PIEZORESPONSE-AFM

PIEZORESPONSE-AFM

(a) Out of plane and (b) In-plane images of PZT(0/20/80). C. S. Ganpule et al., J. Appl. Phys. 91, 1477 (2002). A.L. Roytburd et al., J. Appl. Phys. 89, 553 (2001).

Factors influencing the fate of mammalian gene duplicates Paul Ryvkin*, Jin Jun¥, Edward Hemphill±, Craig Nelson± *University of Pennsylvania, Philadelphia, PA ¥University of Connecticut – Computer Sci and Engineering, Storrs, CT ±University of Connecticut – Molecular and Cell Biology, Storrs CT Introduction Gene duplication has long been recognized as an important contributor to the evolution of organismal complexity. Through duplication, raw material is generated for the diversification of gene function. What happens to genes after they duplicate? Why do duplicate genes sometimes evolve at different rates? We propose that molecular duplication mechanisms, with their varying consequences for duplicates' regulatory information, are the primary influences on the symmetry of duplicate evolution. Several duplication mechanisms have been observed to date, including segmental duplication and retrotransposition. Segmentally duplicated genes preserve intron-exon structure and often preserve flanking intergenic DNA. In retrotransposition, spliced mRNA transcript is reverse transcribed into DNA and re-integrated at a random genomic location[1]. Only recently have studies begun to address the role of duplication mechanisms in the fate of new gene copies[2], particularly that of retrotransposition. Retrotransposed gene copies cannot carry their parent's cis-regulatory material with them and must therefore be subject to novel regulatory influences. In contrast, tandem duplicates...
Potential BEOL Yield Gains from Non-Tree Route Augmentation

Potential BEOL Yield Gains from Non-Tree Route Augmentation

B. Liu, A. B. Kahng, I. Mandoiu u v p q Scanline Speedup yq ≤ yu ≤ yp and xu ≤ xp = xq ≤ xv  cost(u, v) ≤ cost(u, s) + cost(s, v) , s  {p, q}, or, (u,v) can be replaced by (u, p) and (p, v) Enables implementation of line-scanning algorithm which speeds up greedy MRTA from O(n2) to O(n lg n) Given routing tree Augmenting edges Increased wirelength budget potentially enables more efficient augmenting edges (instead of duplicated edges) and results in increased biconnectivity open short

Gene Martin - Managing Director Head of Loan Syndicate Biography Gene Martin joined the Firm in 2003 as a Managing Director and is the Head of Loan Syndicate. He is responsible for the origination, underwriting and distribution of event-driven bank loans and bridge loans for the Firm’s Event Lending Business. Gene has extensive experience originating and executing complex financing transactions (e.g. acquisitions, recapitalizations, hostile takeovers, takeover defenses, exit financing2, rescue financings and refinancings) globally. Prior to joining Morgan Stanley in 2003 , Gene, who has spent fifteen years in the leveraged finance business, worked in Leveraged Finance at Donaldson, Lufkin and Jenrette (DLJ) and then Credit Suisse First Boston (through the merger with DLJ) where he had responsibility for origination and execution of leveraged finance transactions with financial sponsors and media and telecommunications companies. Prior to joining DLJ, Gene worked as a Vice President in Bank of America’s Financial Sponsor Group. Gene, who is a Chartered Financial Analyst, received his MBA from the University of Connecticut School of Business. In addition, he also holds a B.S. from the University of Connecticut

Prof. Suresh Nair * Critical Thinking Inventory Management Brand (product line) extension's impact on inventory management. Conjoint analysis. How would you evaluate the criticality of an item that is out of stock? How would you incorporate substitutes in your inventory calculations? Independence/dependence between items. How do you rate your firm’s inventory visibility? How would you incorporate grouped orders, blanket orders, online orders? How would you cycle count your inventory? What has been the impact of technology on inventory management?
MCB 372 PSI BLAST, scalars

MCB 372 PSI BLAST, scalars

J. Peter Gogarten Office: BPB 404 phone: 860 486-4061, Email: gogarten@uconn.edu
MCB 372 Phylogenetic reconstruction

MCB 372 Phylogenetic reconstruction

Peter Gogarten Office: BSP 404 phone: 860 486-4061, Email: gogarten@uconn.edu
Trees – what might they mean?

Trees – what might they mean?

Calculating a tree is comparatively easy, figuring out what it might mean is much more difficult. If this is the probable organismal tree: species B species A species C species D seq. from B seq. from A seq. from C seq. from D
Databanks (A)

Databanks (A)

NCBI (National Center for Biotechnology Information) is a home for many public biological databases (see an older diagram below). All of the databases are interlinked, and they all have common search and retrieval system - Entrez. Another more complete representation with an interactive display of the number of the connections between the different databases in ENTRZ is here.
the gradualist point of view (review)

the gradualist point of view (review)

Evolution occurs within populations where the fittest organisms have a selective advantage. Over time the advantages genes become fixed in a population and the population gradually changes. Note: this is not in contradiction to the the theory of neutral evolution. (which says what ?) Processes that MIGHT (!) go beyond inheritance with variation and selection? Horizontal gene transfer and recombination Polyploidization (botany, vertebrate evolution) see here Fusion and cooperation of organisms (Kefir, lichen, also the eukaryotic cell) Targeted mutations (?), genetic memory (?) (see Foster's and Hall's reviews on directed/adaptive mutations; see here for a counterpoint) Random genetic drift Gratuitous complexity Selfish genes (who/what is the subject of evolution??) Parasitism, altruism, Morons
Growth and Development ECON 205W Summer 2006 Prof. Cunningham

Growth and Development ECON 205W Summer 2006 Prof. Cunningham
Phylogenetic reconstruction

Phylogenetic reconstruction

Peter Gogarten Office: BSP 404 phone: 860 486-4061, Email: gogarten@uconn.edu
Information About Final Examination Economics 3479W Spring 2009

Information About Final Examination Economics 3479W Spring 2009
Trees – what might they mean?

Trees – what might they mean?

Calculating a tree is comparatively easy, figuring out what it might mean is much more difficult. If this is the probable organismal tree: species B species A species C species D seq. from B seq. from A seq. from C seq. from D Why could a gene tree look like this??

MCB 5472 Types of Selection Peter Gogarten Office: BSP 404 phone: 860 486-4061, Email: gogarten@uconn.edu
MCB 371/372 Sequence alignment Sequence space 4/4/05

MCB 371/372 Sequence alignment Sequence space 4/4/05

Peter Gogarten Office: BSP 404 phone: 860 486-4061, Email: gogarten@uconn.edu
MCB 371/372 positive selection 4/25/05

MCB 371/372 positive selection 4/25/05

Peter Gogarten Office: BSP 404 phone: 860 486-4061, Email: gogarten@uconn.edu
"Nothing in biology makes sense except in the light of evolution"

"Nothing in biology makes sense except in the light of evolution"

Theodosius Dobzhansky

Microarray Technology and Data Analysis (November 28, 2007)  slides assembled by Dong-Guk Shin and J Peter Gogarten
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