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(The University of California, Los Angeles)

The University of California, Los Angeles (UCLA) is a public research university located in the Westwood neighborhood of Los Angeles, California, United States. It was founded in 1919 and is the second oldest of the ten campuses affiliated with the University of California system. UCLA offers over 300 undergraduate and graduate degree programs in a wide range of disciplines and enrolls about 26,000 undergraduate and about 11,000 graduate students from the United States and around the world every year.

More information: http://en.wikipedia.org/wiki/University_of_California,_Los_Angeles

The Concurrent Partnerships Debate: The Contribution of Historical-Ethnography Mark Hunter Social Science/Geography, University of Toronto mhunter@utsc.utoronto.ca

The Concurrent Partnerships Debate: The Contribution of Historical-Ethnography Mark Hunter Social Science/Geography, University of Toronto mhunter@utsc.utoronto.ca
Empowering women culturally and addressing men’s concerns about reproductive health services in a rural community mobilization programme in northern Ghana Philip B. Adongo PhD University of Ghana School of Public

Empowering women culturally and addressing men’s concerns about reproductive health services in a rural community mobilization programme in northern Ghana Philip B. Adongo PhD University of Ghana School of Public

Engaged and Engendered: Women, Men, and Child Spacing in Mali Susan Igras, Marie Mukabatsinda, and Sékou Traore Men, Masculinities and Family Planning Conference, UCLA October 2010
NEW EVIDENCE ON VASECTOMY AND MALE INVOLVEMENT IN FAMILY PLANNING IN RWANDA Joshua Davis, MSPH

NEW EVIDENCE ON VASECTOMY AND MALE INVOLVEMENT IN FAMILY PLANNING IN RWANDA Joshua Davis, MSPH

Treatment The patient was initiated on prednisone and cyclophosphamide, with improvement of the ulcers and her weakness. Discussion MAGIC Syndrome first described in 1995 MAGIC Syndrome is a combination of Behcet’s disease and Polychondritis Patients with Behcet’s typically present with… Recurrent oral ulcers Any of several systemic manifestations including Genital ulcers Ocular disease (i.e. uveitis) Cutaneous lesions (i.e. acneiform lesions) Erythema nodosum Palpable purpura Neuropathy Vascular disease Arthritis Polychondritis usually presents with auricular involvement, though another anatomic areas such as the nose, lungs, heart, and the vascular system may be involved. Associated symptoms include fatigue, malaise, and fever. This patient has features of both diseases: Pulmonary embolism and deep vein thromboses, and non-healing oral and skin ulcers that are similar to those described in Behcet’s disease. The cartilaginous destruction of her ears is classic for polychondritis. The mainstay of treatment is immunosuppression, with azathioprine, methotrexate, or cyclophosphamide. MAGIC Syndrome: Mouth and Genital Ulcers With Inflamed Cartilage Syndrome Rohit Kedia MD, Jason Fish MD, Baldeep Singh MD David Geffen School of Medicine at UCLA, Los Angeles, CA Learning Objectives Review the clinical features and treatment of MAGIC Syndrome (Behcet and Polychondritis’ overlap syndrome). Case Presentation 64 year-old female with long-standing diagnosis of undifferentia...

Internal Medicine Residency Program, David Geffen School of Medicine at UCLA Case Description An exquisitely brief and riveting synopsis of the case. Adhere to the standard sequence of HPI -> PMH -> Fam/SocHx -> PE -> Labs -> Studies. However, not all of the above are necessarily relevant, and may not all be included. Consider breaking the case into sections (e.g. HPI, PMH, PE, etc) to further organize the text for the reader. Use visual dividers to separate sections ROS should be included in the HPI only when it contributes to making the presentation interesting. Give a brief description of the treatment course and finish with the patient’s last known outcome. Discussion Learning Objectives Use action verbs describing your learning goals for the reader, usually recognize, diagnose, manage, etc. Figure 2. EKG Figure 1. Chest X-ray Stella Resident, MD My Special Patient The largest section of the poster – it deserves the most attention. Break your discussion into several headings, use tables and charts to make your points Use section headings (Epidemiology, Clinical Findings, Diagnostic Tests, etc.), bullets and avoid “big-block-of-text” format – these are hard to read If a common presentation of an uncommon disease, explain how it’s like other cases. Review pathophysiology, epidemiology, risk factors, clinical characteristics, optimal diagnostic work-up, and treatment options. If the case is an uncommon presentation of a common disease, explain how it ...

Nothing to Cough About: A Case of Nocardiosis in the Setting of Polymyositis Grant Chu, M.D., Arleen Brown, M.D., Ph.D. Department of Internal Medicine, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA Clinical Presentation A 41-year-old man with a history of polymyositis presented to the emergency department with a 2-week history of worsening shortness of breath and productive cough. He also reported fevers, malaise, night sweats, and weight loss. The patient had a history of being treated with adalimumab, azathioprine, methotrexate, prednisone, and intravenous immunoglobulin for his polymyositis. On examination, he had a temperature of 38.3°C and heart rate of 154; respiratory distress and bibasilar rales on lung auscultation were noted. Laboratory studies revealed a normal white count; arterial blood gas showed a pH 7.43, pCO2 33 mm Hg, paO2 92 mm Hg on 15 liters of oxygen via face mask. Chest radiograph and CT scan of the chest revealed left lower lobe consolidation. The patient was empirically started on broad-spectrum antibiotics. Bronchoscopy was performed also performed on admission. Two days later, bronchoalveolar lavage cultures yielded Nocardia asteroides. The patient received intravenous trimethoprim/ sulfamethoxazole and amikacin. CT scan of the brain showed no abscess. His oxygenation slowly improved as he continued to receive intravenous antibiotics over the next 3 weeks, and he was discharged home with a 6-month course of ...

HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS A Rare Appearance in an Adult Vamsi Krishna MD, Jason Napolitano MD, and Hamed Nayeb-Hashemi MD Internal Medicine Residency Program, David Geffen School of Medicine at UCLA Case Description A 34 year old US NAVY chief officer presented to his doctors with fevers, chills, night sweats, abdominal pain, right axillary lymphadenopathy and weight loss over weeks. He had several admissions at various hospitals and was seen by numerous specialists. An extensive infectious workup was negative. During each of these hospital stays he was eventually discharged without a definitive diagnosis. On a latter admission, he was found to have leukopenia, anemia, low NK activity, and elevated ferritin levels. A right axillary lymph node and bone marrow were biopsied and showed hemophagocytes. Based on clinical and histiopathological findings, a diagnosis of Hemophagocytic Lymphohistiocytosis (HLH) was made. During the patient’s hospitalization, he began to have moderate hepatic dysfunction and severe abdominal pain; a gastrointestinal workup was unrevealing. The patient was transferred to UCLA for further management of his HLH. Several studies were done including cerebrospinal fluid flow cytometry, repeat bone marrow biopsies, repeat infectious workup and PET CT imaging to help exclude T-Cell Lymphoma and confirm an etiology of his HLH. The patient was started on cyclosporine and dexamethasone. Patient was discharged with moderate improvement in his sy...

Sinistral Portal Hypertension:  An unusual cause of UGIB Ajay Dharia, Ryan Hadley MD, Hawkin Woo MD UCLA Department of Medicine, Los Angeles CA Case Description A 35 y/o year-old Samoan male, with a prior medical history of hypertriglyceridemia, chronic pancreatitis complicated by pseudocyst formation and diabetes mellitus, was transferred from an outside hospital to the ICU with a diagnosis of a severe UGIB. He had recurrent episodes of UGIB during the prior nine months requiring multiple hospitalizations, over ten EGDs, a laparoscopy with pyloroplasty and oversew of gastric ulcer, and innumerable transfusions. On the current admission he presented with symptomatic anemia, melanotic stool, and confirmed UGIB with naso-gastric lavage.  He required an emergent EGD, which revealed isolated gastric varices with evidence of recent bleeding but no active bleed.  CT scan showed splenomegaly, varices around the spleen and stomach, a visibly patent splenic vein running through a pancreatic pseudocyst, and an unremarkable liver (See Figure 2). An ultrasound showed patent liver vessels with no abnormal flow patterns.  GI service recommended evaluation for portal hypertension related to liver cirrhosis as well as Banti’s Syndrome (splenomegaly and portal hypertension without liver cirrhosis).  Hepatology was consulted and performed a liver biopsy to fully rule out liver pathology as a source of portal hypertension. When all studies returned negative general surgery was consulted....

MYOSITIS OSSIFICANS RD CALLAHAN1, PGY-II; LAHSKARI, ASHKAN, PGY-III1; B SINGH1, ASSOCIATE CLINICAL PROFESSOR. 1UCLA, Los Angeles, CA. Diagnose and treat Myositis Ossificans. Myositis ossificans refers to benign, extraskeletal bone formation within soft tissue, usually muscle. It most often occurs in males in the second and third decades of life. In 70% of cases, a history of trauma can be elicited, often related to sports injuries. This history may be difficult to obtain, as with our patient, who did not recall trauma perhaps secondary to frequent alcohol intoxication. Eighty percent of cases involve the quadriceps or brachialis muscles. Myositis ossificans occurs in 10% of all quadriceps contusions. Trauma to the muscle triggers proliferative repair with activation of the perimysial tissue-inducible osteoprogenitor cells. Risk factors for developing myositis ossificans include a severe or repeated area of contusion with delays in treatment, use of non-steroid anti-inflammatory agents, application of heat, and presence of a joint effusion. The presentation is frequently similar to that in our patient, with pain, swelling, and decreased range of motion of the involved muscle group. Induration and enlargement of the mass occurs with time. The diagnosis is confirmed by the characteristic radiologic finding of “zoning,” which describes a distinct peripheral margin of mature ossification and a radiolucent center of immature osteoid and primitive mesenchymal tissue. These fi...

Cysteine Reactive Polymers Synthesized by Atom Transfer Radical Polymerization for Conjugation to Proteins Heather D. Maynard, University of California, Los Angeles CHE-0416359 Bontempo, D.; Heredia, K. L.; Fish, B. A.; Maynard, H. D. J. Am. Chem. Soc. 2004, 126, 15372-15373. Polymers were synthesized to have one end that reacts with proteins using a special initiator for atom transfer radical polymerization (ATRP). The reaction with proteins results in a reversible disulfide bond and is specific for one type of amino acid called a cysteine. Proteins decorated with polymer chains are called protein-polymer conjugates. These conjugates are very important in medicine and nanotechnology Graduate student Karina Heredia, postdoctoral researcher Debora Bontempo and Maynard

= 125, 250 mL = 1L = 500 mL
Polymerization from Proteins with Retention of Bioactivity Heather D. Maynard, University of California, Los Angeles CHE-0416359

Polymerization from Proteins with Retention of Bioactivity Heather D. Maynard, University of California, Los Angeles CHE-0416359

Protein initiator Protein- Macroinitiator Protein monomer Protein-Polymer Conjugate Protein Synthesis of Protein-Polymer Conjugates We employed this synthetic method to make T4 lysozyme-polyNIPAAm conjugates. The poly(NIPAAm) is a ‘smart’ polymer that responds to temperature. The bioactivity of the protein was evaluated after each modification (i.e. modification with the initiator and subsequent polymer). The assay showed no loss in bioactivity (left). UV-Vis Activity Assay Heredia, K.L.; Bontempo, D.; Ly, T.; Byers, J.T.; Halstenberg, S.; Maynard, H.D. J. Am. Chem. Soc. 2005, 127, 16955-16960. Proteins are ideal for use in medicine as therapeutic agents and in biotechnology as sensors. Furthermore, attachment of polymers to specific places on the protein improves the protein’s properties. We have developed a method to create these protein-polymer conjugates in which the polymer is grown directly from the protein. This method involves first modifying the protein with a molecule to initiate polymerization, and growing the polymer from the protein-macroinitiator (right).

Range Frequency Expected letter <40 2 E 40 - 44 1 E 45 – 49 3 D 50 - 54 1 D 55 - 59 6 C- 60 - 64 8 C 65 - 69 6 C+ 70 - 74 18 B- 75 - 79 23 B- 80 - 84 9 B 85 - 89 26 B+ 90 - 94 30 A- 95 - 99 13 A 100 - 110 10 A+

One Step Synthesis of Biotinylated ‘Smart’ Polymers Heather D. Maynard, University of California, Los Angeles CHE-0416359 Bontempo, D.; Li, R.C.; Ly, T.; Brubaker, C.E.; Maynard, H.D. Chem. Commun. 2005, 4702-4704. ‘Smart’ polymers respond to environmental cues such as temperature. Conjugates of synthetic ‘smart’ polymers with proteins have important applications in nanotechnology and biotechnology as sensors and switches. We have prepared a well-defined poly(NIPAAm) that has biotin or vitamin H at one end (upper left) in one step. This polymer is not soluble in water at higher temperatures and is soluble at lower temperatures (left). Because the polymer has a biotin at one end, it readily binds to the important protein streptavidin (below). Biotin or vitamin H Poly(NIPAAm) + DT ‘Smart’ polymer solubility in water depends on temperature biotinylated poly(NIPAAm) streptavidin Streptavidin-‘smart’ polymer conjugate

An incomplete picture: GPS inaccuracy and audio upload problems Data Analysis: The Final Frontier Breaking the Norm: the utilization of the G1 mobile phone sensors to recreate a scenario using GPS, audio and tally tags Noemi Agagianian, Nelly Askarinam, Ashley Davis, Jennifer Zehnder, Cameron Ketcham, Rakhee Patel, Sasank Reddy & Deborah Estrin GPS, audio, and tally tag: Visualizations of unconventional scenarios The Problems Discrete Data Collection   Analysis Conclusion UCLA – UCR – Caltech – USC – UC Merced Center for Embedded Networked Sensing Inconspicuous data collectors: The ability to discretely collect data with the tally tags on the G1 phones. Overall: No group displayed any certain reaction; the overall emotion expressed was amusement. This was probably due to the nature of the experiment. GPS: GPS enabled us to further describe a scene because we were able to trace the data collectors' locations. Therefore, outdoor experiments produce better results. It is also important to keep in mind the area of the experiments. In larger areas, results will be more accurate. Future work: If we were given more time, we could combine GPS, audio, and tally tags into a more detailed mapping visualization. GPS, audio, and tally tag: Visualizations of unconventional scenarios The Project Photo and video usage violate privacy rights. Audio enables us to get a sense of the surrounding environment without collecting unethical data fro...

Problem Description: Current localization methods have disadvantages Proposed Solution: A networked localization system that uses both GPS and WiFi Omni-directional WiFi Localization Rohun Bansal, Jessica Chen, Kevin Chen, Nathan Schloss, Deborah Estrin, Cameron Ketcham, Rakhee Patel, Martin Lukac OWL - http://owl.t4so.com/ Introduction: Determining location through use of sensors Sensors on Mobile Phones Modern smart phones (such as the Android G1) have a variety of sensors GPS sensors can generally acquire fairly accurate location data. WiFi devices can scan for access points as well as create ad-hoc networks. Mobile phones are becoming increasingly more widespread As the number of phones in use increases, applications involving networks of phones become progressively more practical to implement. OWL: Localization System UCLA – UCR – Caltech – USC – UC Merced Center for Embedded Networked Sensing GPS: Global Positioning System Requires line-of-sight view to satellites in order to function Although GPS is very accurate outdoors under an unobstructed sky, it works poorly or not at all in environments lacking such a view (notably indoors and near large buildings). Long time to first fix Because each GPS satellite only broadcasts ephemeris data every 30 seconds, the time for a receiver to get a fix is the time it takes to acquire each GPS satellite’s signal plus up to 30 seconds for ephemeris information. WPS: WiFi Positioning System Requires an internet...
Workflow to Use Shibboleth Authentication to Sign X509 Certificate

Workflow to Use Shibboleth Authentication to Sign X509 Certificate

EPPN provides FN: LN: Org: Role: Username: Password: Identity Provider Certificate exits for the ePPN MyProxy Server ePPN/SP-ID Create Certificate Generate proxy Web Service NO Push YES SLC Service Provider Encrypt (RandomPassword, ePPN + SP-ID)) Two ways encryption/decryption Store the encrypted password to DB Retrieve password from DB Decrypt (DBPassword, ePPN + SP-ID)) Two ways encryption/decryption Username/password
Possible Ferritic Steel Structure Fabrication Development Paths

Possible Ferritic Steel Structure Fabrication Development Paths

Seek a formal US/EU collaborative program to develop the ferritic steel structure for TBM. US contributes in key areas such as joint testing and evaluation techniques, generation of qualified materials data, development of NDE techniques and procedures, formulation of appropriate design rules and acceptance criteria, pursue alternate FW designs for improved heat transfer (relaxed He flow channel tolerances), development of specific fabrication routes not presently under investigation (e.g., investment casting for mock-ups). Independently develop the fabrication technology for the ferritic steel structure (including exploration of alternative FW designs). This is a challenging option given the ~$3M invested so far by the EU in fabrication technology development and the relatively short time available to accomplish the task. It is not clear the EU will be able to meet their schedule given the current state of fabrication technology and the level of design analysis and testing performed so far. This approach would likely not give the US access to expensive test facilities for conducting mockup experiments.
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