SlideFinderPowerPoint search engine with thumbnail results
Advanced search
Newest Viewed Downloaded

Universities > United States Showing 1 - 8 of 8 items

(Roger Williams University)

Roger Williams University, commonly abbreviated as RWU, is a private, coeducational American liberal arts university located on 120 acres in Bristol, Rhode Island, above Mt. Hope Bay. Founded in 1956, it was named for theologian and Rhode Island cofounder Roger Williams. The university itself, however, has no religious affiliation.

More information: http://en.wikipedia.org/wiki/Roger_Williams_University

Bryostatin and lactacystin affect PKC activation and Long Term Memory Christopher J Gagliardi, Alan Kuzirian*, Herman Epstein*, Daniel Alkon† and Christie Parish§ Roger Williams University, One Old Ferry Road, Bristol, Rhode Island 02809 Marine Biological Laboratory, 7 MBL street, Woods Hole, Massachusetts 02543 * Blanchette Rockefeller Neurosciences Institute, 9610 Medical Center Drive, Rockville, Maryland 20850 † Methods and Materials We used classic Pavlovian conditioning to train our Hermissenda using two natural stimuli paired to cause a conditioned response. Hermissenda are naturally photopositive, and move towards light. Hermissenda are also inter-tidal organisms, when exposed to a stimulus that mimics the ebb and flow of the tide, like a shaking, Hermissenda contract as to secure them self to a substrate. With these two stimuli paired together, the Hermissenda are trained to contract when exposed to light. Each exposure to light paired with a shaking is called a training event (TE). We are able to determine how well an animal remembers training events by exposing the animals to light only and than measuring there body length change by direct measurement. If an animal contracts, it is said to display recall (retention of memory); however, if it does not move, or if it elongates, it is said to display no recall (no retention of memory). Drugs in our experiments are administered by immersion. The drugs are mixed with seawater and than injected into the lanes of Pl...

Synthesis, characterization, and study of a series of metal complexes based on trans-[Cl(pyridine)4Ru-L]+ (L= NCArX) Meghan M Gordon, Michael R Reardon, Cliff J. Timpson, and Daniel Von Riesen Roger Williams University, One Old Ferry Road, Bristol, Rhode Island 02809 Abstract Over the past three years, a number of studies in our group have been aimed at exploring the photochemical and electrochemical properties of monomeric and dimeric complexes based on trans-[Cl(pyridine)4Ru-L]+. Our current efforts involve the synthesis, characterization, and study of a new series of monomeric complexes of the type trans-[Cl(pyridine)4Ru-L]+ where L is a cyanobenzene derivative, NCArCOOH, NCArCOMe and NCArCHO. The work presented here will detail our efforts to prepare and to purify each of the complexes. Results of the spectroscopic and electrochemical characterization will be presented as well as an assessment of the thermal and photochemical stabilities of each complex. Methods and Materials Spectroscopic grade solvents (Burdick and Jackson, Aldrich, Fisher) and reagents (Aldrich) were obtained commercially and used as supplied. All reactions were conducted under an argon atmosphere and were shielded from ambient light. The complex trans-[ClRu(py)4(NO)](PF6)2 was prepared according to procedures  previously reported by Coe.5,6 Column chromatography was carried out using silica gel 60 (70-230 mesh) (Aldrich) with varying proportions of acetone:dichloromethane (5% to 50% aceton...

Preparation of a 4-(Phosphonato) Pyridine Ligand That Can Efficiently Bind Metal Complexes to Transparent Semiconductive Substrates Aimée L. Fay Cliff J. Timpson, Daniel D. Von Riesen and Michael P. Balogh Roger Williams University, One Old Ferry Road, Bristol, RI 02809-2921 Abstract Three different synthetic approaches to produce the compound 4-(diethylphosphonato) pyridine were attempted. The first two approaches involved attempts to couple diethyl phosphite with 4-bromopyridine via palladium (0) catalyzed coupling reactions. The third approach involved direct substitution of an activated pyridine intermediate with diethyl phosphide anion. In general, the palladium catalyzed reactions resulted in fair yields (~30%) but required a significant amount of chromatograpy to remove unwanted oxidation products. Direct substitution of pyridine with diethyl phosphide anion ultimately yielded ~25% of the desired product in greater than 99% purity by vacuum distillation. Conversion of 4-diethylphosphonato pyridine into the diacid by de-esterification of the diethylphosphonate ester was easily accomplished in near quantitative yield. Preliminary studies reveal the compound can act as a ligand to efficiently bind metal metal complexes to hydroxylated glass and/or semiconductive substrates. Methods and Materials Spectroscopic grade solvents (Aldrich, Fisher) and reagents (Aldrich) were obtained commercially. Solvents were either freshly distilled and/or dried over molecul...

Creating ecological dynamics in the classroom through the use of learner-centered teaching activities Loren B. Byrne Roger Williams University, Bristol, RI

Synthesis, Characterization and Reactivity of a Series of Ruthenium Acetylide Complexes Jason F. Hill and Cliff J. Timpson Roger Williams University, One Old Ferry Road, Bristol, Rhode Island 02809 Abstract Metal complexes based on ruthenium have enjoyed considerable attention due to the ability to extensively manipulate both the electrochemical and the photophysical properties of the complexes by varying substituents on the ligands. Recently, we have become interested in producing metal complexes of the type trans-[ClRu(dppm)2CCPh-4-Y] where Y is -NO2, -H, and -OCH3 in order to quantify the influence the Y substituent has on the metal-based redox potential and it’s ability to labilize the trans- chloride ligand in the presence of Tl+ ion. Following modified procedures of McDonagh et al. for the synthesis of acetylide complexes, we have been able to synthesis trans-[ClRu(dppm)2CCPh-4-H] and trans-[ClRu(dppm)2CCPh-4-OCH3] in good yield. Our efforts to synthesis, purify, and characterize these complexes, along with preliminary kinetic studies of the chloride abstraction reactions will be presented. Methods and Materials Ruthenium acetylide complexes were prepared following modified procedures of McDonagh et al.5 Spectroscopic grade solvents (Aldrich) and reagents (Aldrich) were obtained commercially and used as supplied. All synthetic reactions were conducted under argon atmosphere and products purified by column chromatography using basic alumina (Aldrich) and elut...

Impact of substituents on the metal-based redox potential for a series of complexes based on trans-[Cl(pyridine)4Ru-L]+ where L is a para-substituted derivative of cyanobenzene Laura M. Fischetti, Meghan M. Gordon, Michael R. Reardon, and Cliff J. Timpson Roger Williams University, One Old Ferry Road, Bristol, Rhode Island 02809 Abstract Over the past four years, a number of studies in our group have been aimed at exploring the photochemical and electrochemical properties of monomeric and dimeric complexes based on trans-[Cl(pyridine)4Ru-L]+. Our current efforts involve the continued synthesis, characterization, and study of a series of monomeric complexes of the type trans-[Cl(pyridine)4Ru-L]+ where L is a para-substituted cyanobenzene derivative, NCArCOOH, NCArCOMe, NCArCHO, NCArBr, NCArCl, NCArNH2, NCArOH, NCArCH3, and NCArCN. The work presented here will detail our efforts to prepare and to purify each of the complexes. Correlations between the metal-based E1/2 values and the electron donating or withdrawing effects of the substituents will be discussed. Methods and Materials Spectroscopic grade solvents (Aldrich) and reagents (Aldrich) were obtained commercially and used as supplied. All reactions were conducted under an argon atmosphere and were shielded from ambient light. The complex trans-[ClRu(py)4(NO)](PF6)2 was prepared according to procedures  previously reported by Coe.2,3 Column chromatography was carried out using silica gel 60 (70-230 mesh) (Aldrich) ...

Information Commons New Service Model: Exploring Partnerships Changing Staff Roles Susan McMullen Reference and Information Resources Librarian Roger Williams University Bristol, Rhode Island USA SEDIC November 6, 2007 smcmullen@rwu.edu http://faculty.rwu.edu/smcmullen

Nitric Oxide Production from Synthesized Ruthenium (III) Porphyrins Matthew J. Ranaghan, Jeannette Suh, Stephen K. O’Shea, and Cliff J. Timpson Roger Williams University, One Old Ferry Road, Bristol, RI 02809 Abstract One of the regulatory processes of nitrite in mammalian systems is by its reaction with iron found in porphyrin systems. One important reaction is the production of an Iron (II) nitrosyl from Iron (III) and a nitrite ion. This research investigated Ru (III) porphyrin systems, as it is a possible candidate in blood substitutes and in therapeutic drugs as cofactors. The Ru (III) porphyrin base was varied between octaethylporphyrin, tetraphenylporphyrin, and saturated ring cyclam (1,4,8,11-tetraazacyclotetradecane). The addition of nitrite to varying Ru (III) macrocycles will be monitored with repetitive UV-vis spectroscopy scans in order to determine the rate of reaction for the formation of Ru(II) NO macrocycles. The varyation of the E1/2 redox potential of the Ru (III) center is to be investigated by cyclic voltammetry and correlated to the reaction rate to elucidate the mechanism. Methods and Materials Spectroscopic grade solvents (Aldrich, Fisher) and reagents (Aldrich, Frontier Scientific) were obtained commercially and used as supplied. The complex meso-Tetraphenylporphine (TPP) was prepared according to the procedure previously reported by Adler.7 Purification of TPP was carried out on activated alumina (mesh 80 - 200) column chromatography w...
Sitemap