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Pacific Union College (PUC) is a private Seventh-day Adventist liberal arts college located in Angwin, a small town in the hills above northern California's Napa Valley. While a few masters degrees are offered, PUC is primarily dedicated to undergraduate education. It offers a variety of bachelor's degrees in the liberal arts, and a master's degree in education.
More information: http://en.wikipedia.org/wiki/Pacific_Union_College
Chinese Medicinal Herb Scutellaria barbata Modulates Apoptosis in TRAMP-C1 Cell Line And Tumor Development in TRAMP Mice Brian Y.Y. Wong, Hannah Wong, Amy Shepherd, & Alessandro Cavalcante, Department of Biology, Union College, Lincoln, NE 68506
Chinese Medicinal Herb Scutellaria barbata Modulates Apoptosis in TRAMP-C1 Cell Line And Tumor Development in TRAMP Mice Brian Y.Y. Wong, Hannah Wong, Amy Shepherd, & Alessandro Cavalcante, Department of Biology, Union College, Lincoln, NE 68506Scutellaria barbata (SB) has been used in traditional Chinese medicine for treating various cancers such as liver, lung and rectal tumors. Prostate cancer is the second leading cause of deaths due to cancer among men in America. Transgenic adenocarcinoma of the mouse prostate (TRAMP) mimics heterogeneic tumor progression in human prostate cancer, providing a relevant pre-clinical model for identifying important pathways in tumorigenesis, androgen independence, and metastasis of prostate cancer. Detection of tumor by MRI and palpation are valid surrogate measures of tumor progression in this model. These mice are shown to be excellent models for screening of novel drugs and chemopreventive regimens for potential human use. TRAMP C-1 is a cell line established from the mouse. In this study, we determined the extent of apoptosis and necrosis by labeling the DNA strand breaks of TRAMP C-1 cancer cells on chamber slides after DNase I digestion of the non-treatment control group and incubation with 1mg/ml aqueous extract of SB in the experimental groups for 2 and 8 hours separately using terminal deoxynucleotidyl transferase (TdT) TUNEL assay. Daily oral feeding of male TRAMP mice (9 weeks old) in random groups with sterile water as placebo and experimental groups with 8mg and 16mg of sterile aqueous extracts of SB respectively were also performed. Efficacy was evaluated by the absence of palpable tumor formation. Significant time-dependent apoptotic and necrotic effects of... |
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Induction of Apoptosis on TRAMP-C1 Mouse Prostate Cancer Cell Line & LNCaP Human Prostate Cancer Cell Line by Chinese Medicinal Herb, Scutellaria barbata Hannah H.L. Wong, P. McHenry, Department of Biology, Union College, Lincoln, NE 68506; N. Greenberg, Department of Cell Biology, Baylor College of Medicine, Houston, Tx 77030; and B.Y.Y. Wong, Department of Biology, Union College, Lincoln, NE 68506
Induction of Apoptosis on TRAMP-C1 Mouse Prostate Cancer Cell Line & LNCaP Human Prostate Cancer Cell Line by Chinese Medicinal Herb, Scutellaria barbata Hannah H.L. Wong, P. McHenry, Department of Biology, Union College, Lincoln, NE 68506; N. Greenberg, Department of Cell Biology, Baylor College of Medicine, Houston, Tx 77030; and B.Y.Y. Wong, Department of Biology, Union College, Lincoln, NE 68506*23.8 ± 2.0 4.8 ± 1.3 9.0 ± 5.0 Necrotic Cells 4.5 ± 0.5 5.0 ± 1.8 2.5 ± 1.5 Normal Cells *71.7 ± 3.6 90.3 ± 2.9 88.5 ± 3.5 Apoptotic Cells 8hr 2hr Positive control 4.5 ± 1.5 *15.5 ± 12.5 0 ± 0 Normal Cells 11 ± 2 6.5 ± 5.5 5 ± 3 Necrotic Cells 84 ± 3 *78 ± 7 95 ± 5 Apoptotic Cells 8hr 2hr Positive Control Scutellaria barbata (SB) has been used in traditional Chinese medicine for treating liver, lung and rectal tumor. Prostate cancer is the most common form of cancer among American men. TRAMP C-1 is a cell line derived from transgenic adenocarcinoma of the mouse prostate (TRAMP), an useful model for identifying important pathways in tumorigenesis, androgen independence, and metastasis of prostate cancer. LNCaP is an androgen-dependent human prostate cancer cell line. Endonucleolysis is considered as the key biochemical event in apoptosis that leads to the cleavage of nuclear DNA into double-stranded, low molecular weight DNA fragments (mono- and oligonucleosomes) and single strand breaks (nicks) in high molecular weight DNA. In this study, we determined the extent of apoptosis and necrosis by labeling the DNA strand breaks of these two cancer cell lines on chamber slides (after DNase I digestion of the non-treatment control group and incubation with 1mg/ml of aqueous extract of SB in the experimental... |
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Silybum marianum Induces Apoptosis in Mouse (TRAMP-C1) and Human (LNCaP) Cancer Cells Peter R. McHenry, H. H. L. Wong, Union College, Lincoln, NE; N. M. Greenberg, Baylor College of Medicine, Houston, TX; B. Y. Y. Wong, Union College, Lincoln, NE
Silybum marianum Induces Apoptosis in Mouse (TRAMP-C1) and Human (LNCaP) Cancer Cells Peter R. McHenry, H. H. L. Wong, Union College, Lincoln, NE; N. M. Greenberg, Baylor College of Medicine, Houston, TX; B. Y. Y. Wong, Union College, Lincoln, NE |
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Can't Stop the Music: Dealing with File Sharing on Campus
Steven J. McDonald
Rhode Island School of Design
EDUCAUSE Live!
August 2, 2005
Can't Stop the Music: Dealing with File Sharing on Campus Steven J. McDonald Rhode Island School of Design EDUCAUSE Live! August 2, 2005 |
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