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(Oregon State University)

Oregon State University (OSU) is a coeducational, public research university located in Corvallis, Oregon, United States. The university offers undergraduate, graduate and doctoral degrees and a multitude of research opportunities. There are over 200 academic degree programs offered through the university. OSU's programs in nuclear engineering, ecology, forestry, public health, biochemistry, zoology, oceanography, food science and pharmacy are recognized nationally as top tier programs. In recent years, OSU's liberal arts programs have also grown significantly.

More information: http://en.wikipedia.org/wiki/Oregon_State_University

NOAA NESDIS Cooperative Institutes Proposal Process for 5-Year Institutional Award CICS CIMSS CIOSS CIRA Cooperative Institutes Send Proposals to CoRP Director via Grants.Gov NOAA Grants Management Division DOC General Counsel OEAM Office of Executive Assistance Management U.S. Representatives Notify Respective University Notifies U.S. Representatives Notifies Offices of Congressional Affairs(72-hour Blackout) GMD OEAM Cooperative Institute Program Manager/ Program Specialist STAR REVIEW STAR Program Officers STAR CoRP Director STAR Technical Review STAR Admin Officer STAR Director & Deputy 2006
NESDIS Cooperative Institutes Administrators Workshop

NESDIS Cooperative Institutes Administrators Workshop

Budget Justification/Travel: Be as detailed as possible. Use GMD checklist as a guide.

Agenda: STAR CI Directors’ Meeting Tuesday, June 20 (Burt 193) 8:00 Coffee and Registration 8:30 Welcome (Strub/Freilich/Vandehey/Guch) 8:50 STAR Issues (Powell) 9:35 CoRP & CI Policy Update (Guch) 10:15 Break 10:30 Discussion: CI and NOAA Issues (all) 12:00 Lunch 1:00 CI Highlights (CIMSS, CIRA, CICS, CREST) 2:20 Break 2:30 CI Highlights (CIOSS) 2:50 IOOS Plans (operational ocean observing) 3:10 Plans for operational coastal modeling 3:30 Poster Session 5:00 Return to hotels 6:30 Dinner at Michael’s Landing or on your own. Wed, June 21 (COAS Admin) 8:00 Coffee 8:30 Separate Discussions (NOAA & CI Dirs) 9:30 Summary of Discussions (together) 10:15 Break 10:30 Summary and Action Items (Guch) 11:30 NOAA GMD Discussion (Nelson) 12:30 Lunch 1:30 Adjourn
NESDIS Cooperative Institutes Administrators Workshop

NESDIS Cooperative Institutes Administrators Workshop

Funding for Proposals Propose FY07 submission from Jul-Oct 06. Submit multi-year proposals. Bundle proposals.

Discriminant Function Analysis to Distinguish Barneby’s varieties. Color represents Rydberg’s sections. Only Morphology Morphology with Latitude and Longitude DF 2 DF 1 & 3 Discriminant Function Analysis of Barneby’s varieties. DFA tries to find combinations of characters that optimize groups given these a priori groups.

George Boehlert Professor of Marine Fisheries Director, Hatfield Marine Science Center Oregon State University Research Interests: Marine Fisheries, Coastal Ecosystems, Biological Oceanography

Progress toward the Total Synthesis of Azaspiracid: Construction of the ABC Ring System Rich G. Carter, T. Campbell Bourland and Melissa A. Gronemeyer Department of Chemistry Oregon State University Corvallis, OR 97331 E-mail: rich.carter@oregonstate.edu Group Web page: http://www.onid.orst.edu/~carteric/ Figure 1. Photo of Mytilus edulis.1 Figure 2. Reported locations of isolation in Ireland of the azaspiracids. Introduction. A new class of toxins in shellfish, the azaspiracids (Figures 1 and 2), has been recently observed in mussels harvested in the surrounding waters of Europe. Azaspiracid (1) and its related structures, azaspiracid 2-5 (2-5), have been shown to induce serious injury to the digestive tracts, liver, pancreas, thymus and spleen in mice (Figure 3).2 In addition to their significant biological properties, the azaspiracids represent a daunting synthetic challenge as the parent structure 1 possesses twenty stereocenters and three separate spirocyclic linkages. For these reasons, the azaspiracids have garnered significant recent attention in both the biological and synthetic communities.2-5 This poster discloses the successful construction of the C1-C17 portion of azaspiracid including the crucial C10, C13 transoidal bisspirocyclic array. 1 R1 = R2 = R4 = H, R3 = Me 2 R1 = R4 = H, R2 = R3 = Me 3 R1 = R2 = R3 = R4 = H 4 R1 = OH, R2 = R3 = R4 = H 5 R1 = R2 = R3 = H, R4 = OH Figure 3. The Azaspiracids. Strategy. Due to the structural complexity and siz...

What algae need to grow Light: Light is essential for algae. Access to light limits the size and shape of the reactor. Algae absorb different wavelengths of light depending on their color. Carbon: Algae use carbon, usually in the form of CO2 gas, to grow and make oil. The amount of CO2 available to the algae is therefore a design constraint for algae reactors. Other nutrients: Algae also need other nutrients to survive and flourish, such as elements in seawater or silica. Temperature: Algae are usually sensitive to temperature and cannot get too hot or too cold. This is an important issue for bioreactors that will be located outside. Why algae? In the beginning, there were algae, but there was no oil. Then, from algae came oil. Now, the algae are still there, but oil is fast depleting. In future, there will be no oil, but there will still be algae. So, doesn’t it make sense to explore if we can again get oil from algae? -Oilgae.com Algae is more efficient than other biofuels such s soy or corn oil in terms of nutrients and land. It has the potential to become the fuel of choice for the future, but for this to happen, an economically efficient reactor must be designed. Designing an economically efficient reactor capable of growing algae for use in biofuel production Sponsored by Design objectives Low capital and operating cost High conversion of nutrients to lipids High reproduction rate Temperature f...

Objective: Commercial polymers should be designed for environmental sustainability. Desirable traits are biodegradability and production from cost-effective raw materials with sustainable sources. Our goal is to investigate the following parameters of a potentially biodegradable polymer created from sustainable raw materials: Physical, chemical and structural properties Degradability and environmental impact Usefulness as a replacement technology What are we working on? Area of study: Polyglycerol Tartarate (PGT) Because our team members are not the only ones investigating this material, it was agreed that we would focus on materials created from glycerol and tartaric acid cooked above 80 °C. Last year’s team determined the optimal reaction stoichiometry as a 3:2 tartaric acid to glycerol molar ratio. Thus, our main variables are the cooking time and temperature. What are its application? Housing insulation Because the product foams naturally, insulation presents a natural course to begin investigating applications Commercial insulation is cheap, so we have some pretty tough parameters to beat. First we had to figure out how to make an insulator: Why is this special? Foaming Phenomenon A major consequence of higher cooking temperature is ‘foaming’ Water byproduct escapes as steam until the viscosity of the material becomes so high that it instead forms bubbles that cannot escape Investigations in this phenomenon have included chemical additives and time-lapse ph...

2 Why Biodiesel?1 Homogeneous catalysts require refined oils Free fatty acid content over 0.5 wt% and water bearing oils cause soap and froth formation which reduces productivity and makes separation of products difficult1 Biodiesel Production via Continuous Supercritical Catalytic Packed Bed Reactor Project Objectives Operating Parameters Kinetic Model Gas Chromatography (GC) with a Flame Ionization Detector (FID), used to detect electric current (Response) of eluting compounds, for determining sample composition Two internal standards used for mass determination Certified standards used for ethyl and methyl ester calibrations Molar amount of esters present in product stream ignoring unreacted feedstock alcohol - this excess alcohol is recycled back into the alcohol feedstock storage tank Reaction kinetics modeling of canola and soy bean oil conversion data Reaction rate kinetics change from first to second order with increasing reactor temperature for canola oil Soybean oil continues to be first order with increasing temperature Establish optimal operating conditions for different feedstock oils to obtain the highest production at the lowest operating cost (low energy input and separation cost) Determine feasibility of unrefined natural oil feedstocks obtained from national and local suppliers Develop kinetic model of transesterification reaction under supercritical heterogeneous catalytic continuous flow conditions Conduct economic comparison to classi...

Observed flux in micro-featured device is three times higher than a macro-scale device With the given testing space, water recovery ranges from 2% to 10% for a single pass. Device permeability is estimated to be 373 g/(m2 min) (L/mol) Model shows promise for performance characterization, but more data is needed to become fully functional Conclusions: Microscale Mass-Exchanger for Forward Osmosis: Matthew Bertram, Matthew Cunningham June 2008 Osmosis Principles Microtechnology Analysis Special Thanks To Semi-permeable Membrane: The membrane functions by rejecting the salts (purple, green) while allowing water to pass through. Salts are rejected because of the “hydrosphere” of water molecules surrounding them. Forward and Reverse Osmosis Across a Membrane: Osmosis or forward osmosis harnesses a difference in osmotic pressure to drive water across a semi permeable membrane from one solution to another. water naturally flows across the membrane from low concentration to high concentration. This is known as osmosis. pressure is added to the concentrated side until water moves across the membrane to the dilute side. This is Reverse Osmosis. Mr. Todd Miller (ONAMI) for lab space, and guidance Dr. Ed Beaudry (HTI) for expertise and membranes Dr. Philip Harding for his guidance and mentorship Dr. Alex Yokochi for technical advice and assistance Dr. Goran Jovanovic for additional lab space Microtechnology offers a number of potential benefits over c...

Production Process Four stages to production Algal growth Harvesting through bioflocculation Oil separation Biodiesel production Encapsulation of Algae for the Production of Biofuels Algae based fuel production systems can operate on unused resources. While the cost is restrictive, policy changes or fuel market changes may positivity shift the economic viability. Current algae growth systems are often dominated by undesired local species. Encapsulation by a permeable membrane could allow for sustained growth without contamination. Our project focuses on the design and feasibility of capsules. We are examining capsule permeability, algae growth, and the cost of fuel production. Algae Basics Needs cheap or negative value resources Carbon dioxide Brine water Arid land Algae components and their products Carbohydrates (Ethanol production) Lipids (Biodiesel Production) Proteins (Waste) Encapsulation Porous membrane allows passage of nutrients, but not cells Capsules must be sealed and sterile Experimental capsules must allow sampling Used dialysis membrane (expensive) Could use Cellophane (low-cost) Permeability Tests Displayed right, concentration changes over time due to ion transfer through the porous membrane. Permeability can be calculated from this data. Measuring ion concentration outside capsule with a conductivity probe. The solution in the capsule is a known, high concentration. A first order with respect to concentration gradient relationship was used. C... http://saferenvironment.files.wordpress.com/2008/10/algae_biodiesel.jpg for the one on the right. http://saferenvironment.files.wordpress.com/2008/10/algae_biodiesel.jpg for the on in the poster. Also the text on the right I was thinking about including in the encapsulation portion. Feel free to move anything around. Not sure what else we talked about guys. But I should be around to help out, tomorrow, I do have lab probably till 5 or something.

Demineralized bone matrix (DBM) is used in humans to induce bone formation Spinal fusion surgery, osteoporotic fracture healing, and dental procedures Harvested from human cadaver bones High variability in quality due to factors such as age, gender, and diet Major drawbacks can be overcome by producing osteoinductive proteins in vitro   The goal of the project is to determine if gel encapsulation of bone-forming osteoblasts is a feasible method of cell stabilization for commercial DBM production. Osteoblasts prefer to grow attached to a surface – the alginate matrix of a bead provides sites for adhesion Bone cells respond to physical stress by producing more protein, so agitation may increase yield Alginate weight percent is involved in shear stress transduction, and effects pore size Results Cell viabilities in all experiments were lower than anticipated. In the first experiment, it was due to low inoculation density resulting in poor cell-to-cell signaling. In the second experiment, the viability was higher at about 60% on Day 2, but still low. In the future if work is continued on this project, the following improvements will be made: Purchase Type-1 collagenase for bead digestion Use ELISA (Enzyme-Linked Immunosorbent Assay to determine trace protein concentrations Additional controls for the protein assay Do not use expired materials Introduction We would like to thank Dr. Russell Turner and the Skeletal Research Lab for providing lab space and equipment, Dr. Ph...

Synthesis of Doped Titanium Dioxide Nanoparticles Nanoparticles have been around for millennia, being produced by various natural phenomena. However, since the industrial revolution, the number of nanoparticles in the environment has been increasing steadily. Titanium dioxide nanoparticles are present in many consumer products, such as: Cosmetics Paper Medications Sunscreens Questions will arise, such as is there a buildup of nanoparticles in the food chain, and what affect, if any, do TiO2 nanoparticles have on any form of life? These questions are important because: Nanoparticles have a tremendous potential for the future of our society Overall, the potential environmental and health ramifications are still relatively unknown. Chuang, H.Y., & Chen, D.H. (2008). Catalyst-free low temperature synthesis of discrete anatase titanium dioxide nanocrystals with highly thermal stability and UVC-cut capability . Journal of Nanoparticle Research. 10, 233-241. Li, Y., Lim, S.H, and White, T. (2004). Controlled Synthesis and Characterization of TiO2 Nanoparticles via a Sol-Gel Method. International Journal of Nanoscience. Vol 3, No. 6, 749-755. Gutsch, A., Kramer, M. Michael, G., Muhlenweg, H., Pridohl, M., and Zimmermann, G. (2002). Gas-Phase Production of Nanoparticles. KONA Power and Particle Journal. No. 20, 24-37. Croll, S.G., Taylor, C.A. (2007). Hydrated Alumina Surface Treatment on a Titanium Dioxide Pigment: Changes at Acidic and Basic pH. Journal of Col...
Thermal Inkjet Dispense for Pharmaceutical Research Lindsey Rucker, Hugh Hobbs, Ahson Saeed School of Chemical, Biological, and Environmental Engineering

Thermal Inkjet Dispense for Pharmaceutical Research Lindsey Rucker, Hugh Hobbs, Ahson Saeed School of Chemical, Biological, and Environmental Engineering

HP applies their thermal inkjet printing technology to simplify the drug titration method. One HP consumable print head is loaded, which is capable of dispensing over a range of 15 pL to 1 µL. This leads to reduced labor costs and time requirements, and increased precision. Simplifies drug titration method Leads to reduced labor costs Reduction in time HP Direct Titration Method Traditional Method Drug discovery involves a titration process in which the effects of different concentrations of potential drug compounds are analyzed. Current methods of analysis involve steps which are labor intensive, error prone and, more importantly time consuming. DMSO penetrating in single point Cell death caused by high concentration at points of penetration. No Jitter Immediately after dispense 5 seconds after dispense 1 minute after dispense Cell death No Cell Death Immediately after dispense Jitter Jittering Method “Jittering”: oscillation of the well plate using the stage to induce shear between the deposited fluid, and fluid already in well. The stage can oscillate in the front to back direction (FB) or dual axis (FBLR). Quantitative Method A significant change in counts is caused by the solution not being fully mixed. Once the fluorescence signal, or counts, reaches a steady level, the conclusion can be made that mixing has occurred. This has been determined to be the best method to quantify mixing using kinetic data. Vessel Radius Bond Number Theo...

Heat Transfer in Small Sustainable Thermoelectric Power Sources Matthew Delaney, Nathan Coussens, Russell Austin, Peter Wills School of CBEE, CHE 415-416, 2008 Problem Statement A local start-up company, Perpetua Power Source Technologies, is designing small thermoelectric devices to power wireless sensors. The thermoelectric device relies on a temperature difference to generate electricity. Perpetua is seeking a model, backed by experimental data, which predicts heat transfer within the device, and allow devices to be designed with optimal fin heat dissipation with minimal trial and error. Objective Develop a theoretical model to predict heat transfer rates through a thermoelectric power source composed of varying materials in a cylindrical geometry, and confirm model with experimental results. The Different Modes of Heat Transfer Conductive heat transfer is the transfer of energy from one stationary mass to another. Convective heat transfer describes the exchange of energy from a given mass to a moving liquid or gas. Radiative heat transfer describes the transfer of energy via particles or wavelengths. This would describe the transfer of energy from the sun. Each of these can be modeled individually. However, all three of the modes of heat transfer have some interdependence. For this reason, the conductive, convective, and radiative components need to be integrated into a single model. This model was broken into two components: the cylinder at the base of t...

Hydrogel Composites for Spinal Disc Replacement Who Cares? A 2002 National Health Survey reported that 34 million Americans over 18 have lower back pain. 80% of people will have some form of back pain in their lives, many of them with extruded discs. People with lower back pain are often less productive and have large medical expenses. Disc or nucleus pulposus replacement attempts to remove debilitating pain and restore functionality. Current “Solutions” Composite Perspective Lumbar Decompression Laminectomy – Relieves pressure on nerve root Discectomy – Removal of the nucleus pulposus to relieve pressure on spinal chord Lumbar Spinal Fusion Immobilization of spinal bones via screws to reduce movement related pain This can hasten the degeneration of adjacent intevertebral discs and reduce daily mobility http://brispine.com.au/images/ posterior_fusion_x_ray.jpg Replaces only the central cushion and restores disc height However, this requires a fully functional annulus fibrosus http://www.discdyn.com/procedure.html Nucleus Pulposus Replacement The Problem Total Disc Replacement An invasive surgery that eliminates all damaged disc tissue It restores function, but without properly imitating the actual function http://www.usc.edu/schools/medicine/departments/neurological_surgery/clinical/spina/artdisc.html Objective To evaluate the effects of micro-crystalline cellulose filler in a hydrogel matrix as a potentially injectable nucleus pulposus replacement. http://catal...
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