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Albert Einstein College of Medicine

Albert Einstein College of Medicine (Einstein) is a graduate school of Yeshiva University. It is a not-for-profit, private, nonsectarian medical school located on the Jack and Pearl Resnick Campus in the Morris Park neighborhood of the borough of the Bronx of New York City. In addition to medical degrees, Einstein offers graduate biomedical degrees through the Sue Golding Graduate Division. Allen M. Spiegel, M.D., has served as The Marilyn and Stanley M. Katz Dean since June 1, 2006.
Khodakhah Lab and the Cerebellum: A Love Story

Khodakhah Lab and the Cerebellum: A Love Story

AECOM, Kennedy 506. Beautiful view of parking lot. http://www.aecom.yu.edu/kamlab Karina Alviña, Paola Calderón, Johanna Dizon, Sung-Min Park, Esra Tara, Joy Walter, and Kamran Khodakhah Examining inhibition’s role in Purkinje cell firing rate modulation The cerebellum coordinates the body through its principal neuron, the Purkinje cell. The Purkinje cell integrates over 150,000 cortical and sensory inputs to generate the signals for coordinated movement. Those signals are in the form of a rate code that modulates from the intrinsic rate of ~50 Hz to span from ~1 to ~250 Hz. Firing rates under ~50 Hz require some form of net inhibition from inhibitory interneurons: basket cells and stellate cells. However, their strengths relative to each other and the role of a single interneuron in Purkinje cell firing rate modulation remain unclear. We will clarify these issues using a spike train stimulus protocol in basket and stellate cells while recording from a connected Purkinje cell. Question: Can a single interneuron sustain a GABA conductance to shunt a Purkinje cell’s intrinsic inward currents? A B A. Recording configuration: Purkinje cells are voltage-clamped at -60 mV with a high Cl internal solution. Interneurons are stimulated either extracellularly or in a loose-patch configuration. B. PC IPSCs elicited from an interneuron (basket cell) stimulated at 100 Hz for 1 second (only first four IPSC...
Khodakhah Lab and the Cerebellum: A Love Story

Khodakhah Lab and the Cerebellum: A Love Story

AECOM, Kennedy 506. Beautiful view of parking lot. http://www.aecom.yu.edu/kamlab Karina Alviña, Paola Calderón, Johanna Dizon, Sung-Min Park, Esra Tara, Joy Walter, and Kamran Khodakhah Examining inhibition’s role in Purkinje cell firing rate modulation The cerebellum coordinates the body through its principal neuron, the Purkinje cell. The Purkinje cell integrates over 150,000 cortical and sensory inputs to generate the signals for coordinated movement. Those signals are in the form of a rate code that modulates from the intrinsic rate of ~50 Hz to span from ~1 to ~250 Hz. Firing rates under ~50 Hz require some form of net inhibition from inhibitory interneurons: basket cells and stellate cells. However, their strengths relative to each other and the role of a single interneuron in Purkinje cell firing rate modulation remain unclear. We will clarify these issues using a spike train stimulus protocol in basket and stellate cells while recording from a connected Purkinje cell. Question: Can a single interneuron sustain a GABA conductance to shunt a Purkinje cell’s intrinsic inward currents? A B A. Recording configuration: Purkinje cells are voltage-clamped at -60 mV with a high Cl internal solution. Interneurons are stimulated either extracellularly or in a loose-patch configuration. B. PC IPSCs elicited from an interneuron (basket cell) stimulated at 100 Hz for 1 second (only first four IPSC...

Bronx BREATHES: Resources and Technical Assistance for Improved Tobacco Treatment Barbara Hart, MPA David Lounsbury, PhD Claudia Lechuga, MS Hal Strelnick, MD Bronx Einstein Alliance for Tobacco-free Health MMG QA Council Meeting 5.21.09
Wet, Dry, or Even? Some Ways of Looking at Volume Status without a Pulmonary-Arterial Catheter Anne K. Sutherland, MD Critical Care Medicine St. Barnabas Hospital March 27, 2010

Wet, Dry, or Even? Some Ways of Looking at Volume Status without a Pulmonary-Arterial Catheter Anne K. Sutherland, MD Critical Care Medicine St. Barnabas Hospital March 27, 2010

Delivering Neuro-Critical Care in a Public Hospital: A General Intensivist Experience Raghu S. Loganathan, MD, FCCP Director, Medical ICU & Stroke Center

Delivering Neuro-Critical Care in a Public Hospital: A General Intensivist Experience Raghu S. Loganathan, MD, FCCP Director, Medical ICU & Stroke Center

Generations + Northern Manhattan Health Network Lincoln Medical and Mental Health Center

The evidence: is 24-hour intensivist coverage beneficial? Richard H. Savel, MD, FCCM Associate Professor of Clinical Medicine & Neurology Albert Einstein College of Medicine New York, NY
THERAPEUTIC HYPOTHERMIA FOR CARDIAC ARREST USING PERFORMANCE TARGETS Raghu Loganathan, MD, FCCP Director, Medical ICU & Stroke Center March 2010

THERAPEUTIC HYPOTHERMIA FOR CARDIAC ARREST USING PERFORMANCE TARGETS Raghu Loganathan, MD, FCCP Director, Medical ICU & Stroke Center March 2010

Fiberoptic Bronchoscopy in the ICU

Fiberoptic Bronchoscopy in the ICU

R. Duncalf, MD, FCCP Pulmonary & Critical Care Division Bronx Lebanon Hospital Center
Ultrasound-Guided Arterial Catheterization Ariel L. Shiloh, MD Chief Fellow Montefiore Medical Center 3/27/10

Ultrasound-Guided Arterial Catheterization Ariel L. Shiloh, MD Chief Fellow Montefiore Medical Center 3/27/10

Technology Transfer: An Alternative Career Path Presented by the Offices of Biotechnology and Business Development __________________________________ May 6, 2008

Technology Transfer: An Alternative Career Path Presented by the Offices of Biotechnology and Business Development __________________________________ May 6, 2008

Nutrition Issues: Women's Life Stages Dr. Judith Wylie-Rosett jwrosett@aecom.yu.edu Learning Objectives

Nutrition Issues: Women's Life Stages Dr. Judith Wylie-Rosett jwrosett@aecom.yu.edu Learning Objectives

Identify nutrition issues for a women: During pregnancy focusing on high risk In midlife to reduce chronic disease risk In older age to address multiple medical and/or social problems Assess Weight, Activity, Variety and Excess for each age cycle and determine when refer for medical nutrition therapy with Registered Dietitian (RD) is needed.
RESPONSIBLE RESEARCH CONDUCT

RESPONSIBLE RESEARCH CONDUCT

Human Research Education Program FOR YESHIVA UNIVERSITY FACULTY Federal and Institutional Requirements
Poster Designs from Faculty at the Albert Einstein College of Medicine

Poster Designs from Faculty at the Albert Einstein College of Medicine

Steven L. Bernstein, MD William Burton, PhD William Paredes May 4, 2007
Bronx BREATHES Bronx-Einstein Alliance for Tobacco-Free Health (Bronx BREATHES) NYS DOH Tobacco Control Program Tobacco Cessation Training Program Quarterly Meeting February 4, 2009

Bronx BREATHES Bronx-Einstein Alliance for Tobacco-Free Health (Bronx BREATHES) NYS DOH Tobacco Control Program Tobacco Cessation Training Program Quarterly Meeting February 4, 2009

Intellectual Property Overview for the Academic Researcher

Intellectual Property Overview for the Academic Researcher

AMSTER ROTHSTEIN & EBENSTEIN LLP December 9, 2008 Kenneth George
Khodakhah Lab and the Cerebellum: A Love Story

Khodakhah Lab and the Cerebellum: A Love Story

AECOM, Kennedy 506. Beautiful view of parking lot. Karina Alviña, Paola Calderón, Johanna Dizon, Kathryn Harper, Caroline Hoang, Joy Walter, Kamran Khodakhah free cytosolic Ca2+ UV pulse InsP3-mediated Ca2+ release in Purkinje cells Cytosolic calcium is tightly regulated such that the concentration inside the cell is thousands-folds lower compared to outside the cell. This enables small increases in cytosolic calcium to act as a signaling mechanism within cells. Activation of inositol (1,4,5)-trisphosphate (InsP3) receptors releases calcium from the endoplasmic reticulum, thereby increasing cytosolic calcium levels. Calcium release from these receptors can signal for diverse cellular processes such as gene transcription, fertilization, and transmitter release. The absence of a functional InsP3 receptor in mice results in motor dis-coordination (ataxia) which is associated with impairments in cerebellar Purkinje cells. Ideally, if calcium release through InsP3 receptors is used as a signaling mechanism in Purkinje cells then they should be suited to respond to the fast pace of neuronal activity. In non-neuronal tissues InsP3 signaling is slow, requiring hundreds of seconds between release periods due to calcium inactivation. Currently, the time course for recovery between release periods for InsP3 receptors in intact Purkinje cells is not known. Question: Has InsP3 signaling in Purkinje cells adapted to cope with the fast pace of neuronal activity? Methods A ...
Introduction to the Offices of Biotechnology & Business Development John L. Harb Director, Office of Biotechnology __________________________________ October 30, 2008

Introduction to the Offices of Biotechnology & Business Development John L. Harb Director, Office of Biotechnology __________________________________ October 30, 2008

Nicotine Replacement Therapy: Administration and Overview Barbara Hart, MPA and Claudia Lechuga, MS Bronx BREATHES T: (718)430-2601 E: bhart@aecom.yu.edu / clechuga@aecom.yu.edu www.bronxbreathes.org June 15, 2009

Nicotine Replacement Therapy: Administration and Overview Barbara Hart, MPA and Claudia Lechuga, MS Bronx BREATHES T: (718)430-2601 E: bhart@aecom.yu.edu / clechuga@aecom.yu.edu www.bronxbreathes.org June 15, 2009

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