Merz, B. N Engl J Med 2003;348:975-976 Interrupting Allergy
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Merz, B. N Engl J Med 2003;348:975-976 Interrupting Allergy
Allergy. The binding of IgE to mast cells triggers the release or synthesis of histamine, leukotrienes, and other mediators of anaphylaxis. Anti-IgE antibodies suppress mediator release by forming complexes with free IgE, thus preventing it from binding to mast cells.
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