Kay, A.B. N Engl J Med 2001;344:109-113 Proposed Mechanisms of Specific Immunotherapy (Hyposensitization or Desensitization)
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Kay, A.B. N Engl J Med 2001;344:109-113 Proposed Mechanisms of Specific Immunotherapy (Hyposensitization or Desensitization)
4. Proposed Mechanisms of Specific Immunotherapy (Hyposensitization or Desensitization). Specific immunotherapy is associated with down-regulation of the cytokines produced by Th2 cells, up-regulation of cytokines produced by Th1 cells, and the induction of regulatory T cells. These changes in turn lead to the inhibition of allergic inflammation, increases in cytokines that control the production of IgE (interferon-{gamma} and interleukin-12), the production of "blocking" antibodies (IgG), and the release of cytokines involved in allergen-specific hyporesponsiveness (interleukin-10 and transforming growth factor {beta}).
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