The sampling in Italy Giuseppe Passarino
Dipartimento di Biologia Cellulare
Università della Calabria
Rende, Italy Caposuvero 6-7 June 2003 ECHA Project Mid Term Review Symposium
The sampling in Italy Giuseppe Passarino
Dipartimento di Biologia Cellulare
Università della Calabria
Rende, Italy Caposuvero 6-7 June 2003 ECHA Project Mid Term Review Symposium
Calabria has 2,047,000 inhabitants
The ECHA sampling in Calabria Analysis of the demographic structure of the Calabrian population, especially focused on oldest olds.
Definition of the probands and of Concordant and Discordant sibs according to the features of the Calabrian population.
Population screening to search the probands and their sibs.
Contact with the probands and their relatives, administration of the questionnaire and collection of the blood sample.
Age Distribution of Calabrian Population
Age Distribution of Calabrian Population older than 90
Male/female ratio among centenarians in Italy The male/female ratio among centenarians increases from South to North Italy
Male/female ratio among centenarians in Italy compared to the first genetic component
The ECHA sampling in Calabria Analysis of the demographic structure of the Calabrian population, especially focused on oldest olds.
Definition of the probands and of Concordant and Discordant sibs according to the features of the Calabrian population.
Population screening to search the probands their sibs.
Contact with the probands and their relatives, administration of the questionnaire and collection of the blood sample..
Probands and Concordant and Discordant Sibs in Calabria. Probands are females 99 years or older and males 97 years or older. Concordant are Proband’s brothers who are 92 or older and proband’s sisters who are 94 or older Discordant are proband’s brothers dead at 55-75 years and proband’s sisters dead at 60-80 years.
The ECHA sampling in Calabria Analysis of the demographic structure of the Calabrian population, especially focused on oldest olds.
Definition of the probands and of Concordant and Discordant sibs according to the features of the Calabrian population.
Population screening to search the probands and their sibs.
Contact with the probands and their relatives, administration of the questionnaire and collection of the blood sample.
The of name of any newborn baby is put in the Anagrafe schedules , where her/his family ties are registered (parents, siblings). In addition she/he is put in the Anagrafe Book, as a subject living in that Municipality.In this book date and place of birth are reported. Municipality A Municipality B Municipality C
When a subject moves to a different municipality she/he is put in the Anagrafe book of the new municipality and is erased from the previous one. When a person dies, death is registered in the Anagrafe book and in the Anagrafe schedules. Municipality C Municipality B Municipality A
In the Anagrafe Book we can find all the persons living in a municipality. If we want to know about sibs and parents of a subjects we look up the Anagrafe schedules of the Municipality where she/he was born.
Population screening to search the probands and their sibs: the strategy. All the Calabrian Municipalities (409) were asked to provide us with the names of living subjects born before 1907.
From the lists obtained we identified the probands (males 97 or older, females 99 or older).
The probands were then searched in the Anagrafe schedules of the Municipality where they were born to find out if they had sibs who met the ECHA criteria to be Concordant or Discordant
Finally, the subjects were contacted.
Population screening to search the probands and their sibs: results. So far 283 (out of 409) Calabrian Municipalities have provided the list of living subjects born before 1907. The population of these municipalities account for 1,467,000 inhabitants out of a total of 2,047,000.
379 possible probands (out of 892 identified in the anagrafe lists) have been checked in the Anagrafe schedules to find out if they have concordant or discordant sibs. In the Anagrafe lists obtained from the Municipalities we identified 892 subjects whose age met the ECHA criteria for being a proband: 437 Females (99 years or older) and 455 Males (older than 97).
Population screening to search the probands and their sibs: results.
Population screening to search the probands and their sibs: results. From the analysis of the Anagrafe schedules 103 probands were found to have a discordant sib while 52 were found to have a concordant sib. The remaining ones had no sibs or had sibs that did not meet the ECHA criteria of concordance and discordance.
The ECHA sampling in Calabria Analysis of the demographic structure of the Calabrian population, especially focused on oldest olds.
Definition of the probands and of Concordant and Discordant sibs according to the features of the Calabrian population.
Population screening to search the probands and their sibs.
Contact with the probands and their relatives, administration of the questionnaire and collection of the blood sample.
The probands identified are contacted by phone to ask if they (and their children and nephews) are willing to be part of the study. If they are available we go to see them, administer the questionnaire and draw the blood. The ECHA sampling in Calabria: the contact with the probands
To date we have recruited (interviewed and drawn the blood): 74 probands of Generation 1 89 subjects of Generation 2 The ECHA sampling in Calabria:results We have 42 families with a proband, his/her child and nephew plus some cases where we have some components of the family (for instance only the proband) and we are going to collect the others.
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