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Therefore, all liability for costs or damage resulting from information and conclusions in this document is excluded 2010 BUTALCO
BUTALCO is developing proprietary technologies to produce second generation biofuels and other bio-based products with yeasts
Executive Summary Profile of BUTALCO BUTALCO is a start-up company, founded in August 2007, with its headquarters in Zug/Switzerland and research resources at Goethe-University Frankfurt and at University of Stuttgart-Hohenheim/Germany
BUTALCO is a research company focused on yeast and biofuel technology
BUTALCO carries out own research to develop new technologies for second generation biofuels and biochemicals based on lignocellulose
The core technology based on genetically optimised yeasts (Saccharomyces cerevisiae) enables increased yields in bioethanol production by using C5 sugars as well as the production of advanced biofuels like biobutanol
BUTALCO develops technologies in the field of lignocellulose hydrolysis, fermentation technology and downstream processing together with partners
BUTALCO's aim is to become a global leading yeast-based biofuel company 2010 BUTALCO
BUTALCO Technology 2 Company Overview 1 Content Production Costs 3 Realisation Strategy 4 2010 BUTALCO
BUTALCO was founded in August 2007 and is focused on the development of second generation biofuels and other bio-based products
Company Overview - Key Facts Business Model Development of yeast technology to produce second generation biofuels and other bio-based products
Build-up of own intellectual property
Licensing business (together with partners)
Development of technologies in the field of lignocellulose hydrolysis, fermentation technology and downstream processing together with partners
Flexible partnerships with producing companies and no own production facilities Research activities with 5 scientists based on co-operation contracts with the University Frankfurt and University Stuttgart-Hohenheim
Five patent applications claiming important bottleneck technologies
Co-operation agreements with industrial partners
Wind energy company Volkswind GmbH as investor
Well-known in the biofuels community with much interest shown, especially from governmental institutions Milestones 2010 BUTALCO
Founders are Eckhard Boles, Professor of Molecular Biosciences at Frank-furt University, and Gunter Festel, founder of FESTEL CAPITAL
Company Overview - Founders Founder of the advisory and investment firm FESTEL CAPITAL
Previous positions
Member of the management team and head of the consulting business for the chemical and healthcare industry with Arthur D. Little in Zurich
Consultant with McKinsey in Frankfurt, Brussels and London
Various management positions in R&D and marketing with Bayer AG
PhD and MA in chemistry, BA in business studies and MA in economics, Executive Master of Corporate Finance
Co-founder and member of the advisory board of the Association for Chemistry & Economics
Founding member and member of the executive council of the China Association for Management of Technology Dr. Gunter Festel Professor Dr. Eckhard Boles Professor of Molecular Biosciences at J.W. Goethe University Frankfurt since 2002
Research focused on metabolic engineering of yeast strains for industrial purposes and transport of nutrients across the yeast plasma membrane
Strong experience in using molecular genetics and molecular biology methods to study and manipulate sugar metabolism in yeast
Published more than 60 articles in international peer-reviewed journals, and contributed to 10 important patents in the field of yeast biotechnology
Landmark patents were the construction of the first recom- binant yeast strain able to ferment the pentose sugar L-arabinose, and the functional expression of a bacterial xylose isomerase in Saccharomyces cerevisiae for efficient xylose fermentation 2010 BUTALCO
BUTALCO, headquartered in Zug/Switzerland, currently has “virtual” structures with a zero fixed cost base
Company Overview - Organisation Headquarters BUTALCO GmbH
Schuermattstrasse 1
CH-6331 Huenenberg / Zug
Phone +41 41 780 1643 Festel as interim CEO with no salary
No expenses for personnel and advisory board
“Virtual” structure with effective and lean processes
No overhead costs, 100% of the money raised from Volkswind spent on research
Establishment of a full-time management team consisting of Boles, Festel, Weber and external experts, as soon as possible Organisation 2010 BUTALCO
BUTALCO uses research resources at the University of Frankfurt/Main based on various research contracts
Company Overview - Research Member of the Institute of Molecular Biosciences at Frankfurt University
Research Manager of the BUTALCO project since October 2008
PhD degree in biology (plant biotechnology)
Profound knowledge in microbiology, molecular biology, genetics and biochemistry
Strong experience in yeast technology
Worked on various industrial projects and developed biotechnological processes for the production of fine chemicals with meta- bolically engineered yeast
(Co) author of four publications in international peer-reviewed journals Dr. Christian Weber Frankfurt University / BioCampus
Max-von-Laue-Strasse 9
D-60438 Frankfurt/Main
Phone +49 69 798 29 513 R&D Facilities 2010 BUTALCO
BUTALCO uses research and small-scale production resources at the University of Stuttgart-Hohenheim based on a research contract for 3 years Company Overview - Research R&D Facilities University of Hohenheim/Stuttgart Inst. of Fermentation Technology with Distillery
PD Dr. Thomas Senn
Pilot plant
4 x 1.5 m3 fermenters
Steam explosion
Destillation
S1 (GMO) 2010 BUTALCO
BUTALCO is supported by an advisory board with international experts in the field of biofuels and yeast technology
Company Overview - Advisory Board Current Advisory Board Helmut Lamp
Member of the German Parliament and Chairman of the Executive Committee of the German BioEnergy Association
More information: www.helmut-lamp.de, www.bioenergie.de Prof. Dr. Uwe Sauer
Professor at the Institute of Molecular Systems Biology at the Swiss Federal Institute of Technology Zurich
More information: www.imsb.ethz.ch/researchgroup/sauer Dr. Thomas Schlick
Managing Director, VDA Verband der Automobilindustrie
More information: www.vda.de 2010 BUTALCO
BUTALCO has raised around 1 million Euro from Volkswind in its first round of external financing
Company Overview - Investor Volkswind as Investor Volkswind is a leading European Independent Power Producer of wind energy
Core business is to develop, build, own and operate renewable energy wind power plants
Volkswind is meanwhile a large land owner and is looking for utilisation possibilities for the biomass
The company's headquarter is based in Ganderkesee, Germany, and it has further subsidiaries in France, Great Britain, Poland and Bulgaria
The funds have enabled BUTALCO to strengthen its established research activities
Volkswind has the financial strength to build-up production capacities for lignocellulosic ethanol/butanol 2010 BUTALCO
Company Overview 1 Content BUTALCO Technology 2 Production Costs 3 Realisation Strategy 4 2010 BUTALCO
The core competencies of BUTALCO are the optimisation of yeasts for the production of molecules and as a drug screening method
Yeast-based
Biorefineries Glucose Other sugars Pentoses Butanol Ethanol Organic acids Fine chemicals Butanol
derivatives Bio-
polymers Isoprenoids
Drugs
Lipids Biomass BUTALCO
Yeasts Fermentation Extraction NADH, Glutathion, Glucan,… Hydrolysis Yeast-based
Protein Expression BUTALCO
Yeasts Drug Screening Assays BUTALCO
YEAST
DESIGN BUTALCO Technology - Overview Evaluation of other yeast related technologies and development
Bioactives for the pharma and cosmetics industry
Drug screening assays 2010 BUTALCO
BUTALCO's aim is to become a global leading yeast and biofuel technology company
Biofuel Technology Yeast Technology Biofuels
Bioethanol
Biobutanol
Other molecules
Bio-based chemicals
Bioactives
Drug discovery Core competence is the under- standing of biofuel technologies / markets and partnering concepts Core competence is the modification / optimisation of yeasts with genetical methods to produce molecules Production of bioethanol by yeast using C5 and C6 sugars
Production of biobutanol by yeast using C5 and C6 sugars
Hydrolysis of lignocellulose
Downstream processing
Fermentation technology BUTALCO Technology - Overview 2010 BUTALCO
Yeasts as production organisms for biobutanol and other products have decisive advantages compared to other microorganisms
BUTALCO Technology - Advantages Yeast Advantages of Yeast It is much more probable that ethanol producers in Brazil, Europe or North America will use yeasts rather than bacteria should they switch from ethanol to butanol Yeasts are among the best known microorganisms and are easy to genetically modify
Yeasts have GRAS (Generally Recognized as Safe) status
Yeasts are well established in production processes with a high robustness
Yeasts are highly resistant to toxic inhibitors and fermentation products, and ferment sugars at low pH values
Yeast production processes have a minimized contamination risk
The production process is easier to control compared to other microorganisms
All ethanol production facilities worldwide use yeasts and yeasts have a high acceptance among ethanol producers 2010 BUTALCO
Lignocellulosic biomass Glucose C6 Pentoses C5 C3
Pyruvate CO2 Lipids
(biodiesel) Acetyl-CoA C2 Ethanol Isobutanol Higher alcohols 1-butanol Isoprenoid-
derived fuels CO + H2 2010 BUTALCO ALGENOL GEVO BUTALCO DUPONT LS9 AMYRIS IOGEN COSKATA GREEN BIOLOGICS MASCOMA Feedstocks Biofuels BUTALCO Various feedstocks can be converted into various kinds of biofuels SOLAZYME BUTALCO Technology – Competing technologies
Yeasts will most probably enable the technology switch to lignocellulose as feedstock and advanced biofuels like biobutanol
BUTALCO Technology - Technology Phases Technology Phases Sugar / starch bioethanol with yeast Lignocellulose biobutanol with yeast Sugar / starch bioethanol with other microorganisms Other advanced biofuels Lignocellulose bioethanol with yeast Lignocellulose biobutanol with other microorganisms 2008 2014 2010 2012 2009 2011 2013 Activities of BUTALCO 2010 BUTALCO
Lignocellulosic ethanol production is one of the core technologies to solve today's energy problem
BUTALCO Technology - Lignocellulosic Ethanol Hydrolysis Lignocellulose Sugars Fermentation Destillation and Extraction Addition of
Butalco Yeasts Bioalcohols Electricity/
Steam Chemicals Biomass Shredding Addition of
Enzymes or chemicals 2010 BUTALCO
Lignin 21-32% Cellulose 33-51% Extractives 1-5% Hemicellulose 19-34% sugars...
glucose mannose galactose rhamnose xylose arabinose HEXOSES PENTOSES S. cerevisiae efficiently ferments hexose but is not able to ferment pentoses FERMENTATION
INHIBITORS Composition of lignocellulosic hydrolysates BUTALCO Technology - Hydrolysates 2010 BUTALCO
BUTALCO yeasts will use many more sugars in the fermentation process compared to wild-type yeasts and will produce various molecules
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