WP3:
POSITIVE RESULTS AND DIFFICULTIES G. De Benedictis
WP3:
POSITIVE RESULTS AND DIFFICULTIES G. De Benedictis
THE ADVANCEMENT OF WP3 DEPENDS PRIMARILY ON THE SUCCESS OF WP1 W W W P P P . . . 1 1 1 Sampling 0-26 months W W W P P P . . . 3 3 3 Genotyping of Stress- Responder Genes 3-30 months
Comments on WP 1 The sampling procedure resulted more expensive and laborious than expected. The ECHA funds required to be integrated by other funds
DIFFICULTIES IN SAMPLING
(IN BOTH D AND C PAIRS) D C Rate of pedigree reconstruction Cousins living in different places Missing info on the centenarian’s sib Spread of sampling locations
COMPLETION OF THE SAMPLING PHASE WILL REPRESENT THE MAJOR ADDED VALUE OF THE ECHA PROJECT COLLECTION OF BIOLOGICAL MATERIAL
COLLECTION OF QUANTITATIVE DATA IN ELEDERLY PEOPLE AND THEIR RELATIVES
COLLECTION OF DATA FOR SYNCHRONIC STUDIES
STARTING POINT FOR LONGITUDINAL STUDIES
THE RATE OF TYPING FOR THE AVAILABLE SAMPLES IS NOT LIMITING 249 SAMPLES TYPED FOR 4 LOCI (5 MARKERS)
APPROX 50% TYPED FOR 2 ADDITIONAL LOCI (1 MARKER EACH)
EXPECTED TIME FOR TYPING OF THE NEWLY COLLECTED SAMPLES: AS PLANNED IN THE TIMETABLE
Conclusive Remarks Designing the (possible) re-orientation To redistribute sample sizes of D/C cousin-pairs to achieve the ECHA objectives (all groups pooled)
Orienting the sampling effort towards the most informative pairs
Focusing the genotyping on markers tailored on the analytical procedures
Comments